Synaptic vesicle docking: a putative role for the Munc18/Sec1 protein family.
نویسندگان
چکیده
At presynaptic nerve terminals, neurotransmitter is stored in small membranebound organelles, termed ‘‘synaptic vesicles.’’ In order to release their contents into the synaptic cleft via membrane fusion, synaptic vesicles must first associate, or ‘‘dock,’’ with the plasma membrane. Recent data suggest that the cytoplasmic protein UNC-18 (a.k.a. nSec1/Munc18-1/rbsec-1 or Rop) promotes synaptic vesicle docking through an as yet uncharacterized pathway. Here, we present an overview of synaptic vesicle exocytosis, review the
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عنوان ژورنال:
- Current topics in developmental biology
دوره 65 شماره
صفحات -
تاریخ انتشار 2005